author(s)
Fahmi S Moqbel, Mohammed AY Al-Eryani and Fahd M Abd Al Galil

abstract
The present study has been done to evaluate the effect of abamectin on kidney function and histological changes in mal albino rats. The animals were divided into three groups; group1 rats were injected interaperitoneal with a drop of distilled water (0.1 mg/kg) for a period of 15 days and kept under control. And the other two treated groups (1T and 2T) were also daily injected interaperitoneal with abamectin with dose of 0.1 and 0.6 mg/kg body weight respectively for the same period of 15 days. Rats were sacrificed and blood samples were collected immediately from each rat separately in dry clean centrifuge tubes. Blood samples were centrifuged (3000 rpm for 15 min) and plasma was separated to estimate the Creatinine and urea. Tissue sections from the kidney of the control and the treated groups were prepared and stained with haematoxylin and eosin and observed under the microscope. The present results showed that the body weight of rats in the group-1 (control) increased gradually from around 156g to 205.9g in 15 days while in the treated groups 1T and 2T body weight decreased from 268g and 203.6g as initial weight to 259.5g and 196g respectively. The result also showed that the treatment with abamectin caused significant increase in creatinine and urea concentrations compared to control animals Histopathological examination of rat kidneys revealed Congested B.V, Glomerular shrinkage, Glomerular degeneration, Medullary tubular degeneration and Medullary tubular casts in rats treated with abamectin. Data analyses were done by using one way ANOVA at the level of (P<0.05). The results of current study indicated that the abamectin had a great toxic effect on kidney function which causes significant changes in urea and creatinine. Likewise, pathological examination showed abnormalities in the structures of kidney tissues.