Alpha Lipoic acid role on pituitary testicular function in mice treated with Nitrofurantoin or Methotrexate
Tahani SS Al-Azawi and Mohammed H Asker
This experiment was designed to investigate the antioxidative role of alpha lipoic acid against the reproductive adverse effect of some drugs. Thirty adult male swiss albino mice were divided in to six groups. Two of them were treated with Nitrofurantoin (NFT) or Methotrexate (MTX). Three groups were supplemented with (10mgkg B.wt) Alpha Lipoic acid (ALA) either alone or with NFT or MTX. The sixth group was administered with distilled water as a control. The results reveal an increase in LH, FSH and Testosteron with a decrease in MDA concentration in serum of mice supplemented with ALA. Moreover, these groups showed a significant decrease in the percentage of dead and abnormal sperms with an increase in sperm motility and concentration. It was concluded that ALA supplementation could protect the male reproductive system against deleterious effects of NFT or MTX through its antioxidant role.