Sub-involution of placental sites (SIPS) is a disorder which generally occur in bitches of younger than three years of age after the first whelping when normal healing of the sites of placenta where fetuses attached to the endometrium does not occur and is characterized by the freshly discharged blood from the vulva from several weeks to months post partum. Prolonged or premature parturition may be the predisposing factor to SIPS. Diagnosis of SIPS is based on the history and clinical sign of disease. Vaginal smear and ultrasonography can also be deployed as diagnostic tool. Vaginal cytology has practical application in the evaluation of trophoblastic cells finding indicative of SIPS. However, the most appropriate confirmative tool of diagnosis is the biopsy and histopathology of the affected uterus. Single shot of medroxyprogesterone through parentral (S/C)route is the best studied treatment till date.