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Journal of Entomology and Zoology Studies
Volume 1, Issue 3
Troponin T as the Best Biochemical Markers in the Detection of Myocardial Infarction
Author(s): Merije ELEZI 1*, Anila MITRE 2, Tefta REXHA 3
1. State University of Tetovo, Faculty of Food Technology and Nutrition, Gostivar, Macedonia.
2. State University of Tirana, Faculty of Natural and Mathematical Sciences, Department of Biology, Molecular Biology Section, Tirana, R. Albania, University Hospital “Mother Theresa”
3. State University of Tirana, Faculty of Natural and Mathematical Sciences, Department of Biology, Molecular Biology Section, Tirana, R. Albania.
Abstract: We examined the value of serum levels of cardiac troponin T, serum creatine kinase MB (CK-MB) in the 155 patients within 24 hours of the onset of symptoms, presenting to the University Hospital “Mother Theresa” with a history of one or more episodes of angina and ECG confirmation of MI by the cardiologist. In preliminary observations, we found that the quantum of increase in troponin-T was disproportionate to that of CK-MB. This study was conducted in 6 different groups based on the level of serum troponin T. It was determined by means of a third generation assay (sandwich immuno assay) based on electrochemiluminescence (Elecsys, Roche Diagnostics). CK-MB was also determined on Coobas (Roche Diagnostics). According to the methods employed, control population should have troponin T levels <0.010 ng/ml and CKMB< 20U/L. Patients with symptoms of angina had significantly higher troponin-T and CK-MB levels when compared to healthy controls (p<0.001). In the group 3 with 33 patients the troponin-T value (0.1-1.9mg/ml), p=0.363 (r=0.363 ). The value of TNT were not proportionately elevated with CK-MB value (5.8-18.2U/L), p=0.018 (r=0.338). In cases of severe heart attack myocardial coefficient of correlation between two parameters under consideration resulted r = 0.954, with signifikance p <0.01. cases of severe heart attack myocardial coefficient of correlation between two parameters under consideration resulted r = 0.954, with signifikance p <0.01. Troponin-T levels can be used to detect early and minimal myocardial injury, but CK-MB is not sensitive enough to diagnose this. Initial troponin-T determination drawn at the time of the patients’ presentation is a powerful diagnostic tool for a rapid diagnosis rather than serial CKMB determination.
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