The resistance to chemical insecticides among mosquito species has been considered as a setback in vector control. The present study is focused on natural products of plant origin with insecticidal properties for control of insect vectors. Aqueous, ethanol, methanol, acetone and chloroform extracts of Lantana camara aculeata were evaluated against the fourth instar larvae of three important medically significant mosquito species namely Aedes aegypti, Anopheles stephensi and Culex quinquefasciatus. Phytochemical screening of the leaves showed the presence of phytocompounds such as tannins, alkaloids, flavonoids, anthocyanin, quinines, triterpenoids, flavonoids, saponin and steroids. The leaf extract was also subjected to GC-MS analysis. The percentage mortality of the different mosquito species was tested after 24 hrs of exposure to different concentration of the leaf extract. The extracts of this plantrnshowed potent larvicidal efficacy and can be considered for further investigation.