Introduction: Gelofen (Ibuprofen) is a non-steroidal, non-inflammatory drug that is used to relieve moderate to severe pains. However, the drug has proven side effects such as production of free radicals and interfacing with cellular events. So finding a proper antioxidant is necessary to reduce the side effects of this drug. It was determined that Gelofen by disorder in prostaglandins function and production of free radicals can probably damage liver tissues. Use of soybean extract as a proper antioxidant is recommended in this article to reduce Gelofen induced-complications. For the present experiment, 56 rats were randomly divided into 7 equal groups that received different dose of Gelofen and soybean. After anesthesia histological studies were performed on their livers. The results show that liver tissues in the Gelofen groups had extensive degenerative changes, centrilobular necrosis, lymphocyte accumulation and bleeding. And these changes improved in the soybean groups.