The incidence of obsessive-compulsive and depression disorders increases prescription serotonin reuptake medicines and taking these medicines have several side effects on reproductive system, especially on sexual hormones in male. Nowadays, the approach for reducing side effects of chemical drugs is medicinal plants usage. So, the purpose of the study is investigation on antioxidant effects of ginger rhizome extract for reducing of Clomipramine effects on testosterone, LH and FSH hormones. 42 adult male rats were divided into control, sham, and experimental groups. Experimental group 1 only received Clomipramine and experimental groups 2, 3, and 4 received rhizome extract with Clomipramine. At the end of 21 days blood samples were collected and Radioimmunoassay method was used to measure serum levels of LH, FSH and testosterone hormones. It is found that Clomipramine medicine has damaging effect on sexual hormones and ginger extract improves secretion of these hormones due to its antioxidant properties.