author(s)
Sabet ghadam Mahsa, Dehghani Naeimeh, Danesh pazhouh Hamed, Kargar Jahromi Hossein, Shafiei Jahromi Nazanin

abstract
Today, the global approach for treatment of many diseases, particularly diseases related to survival of generation and infertility is toward use of medicinal plants instead of consumption of chemical drugs. So, this study will compare the effect of metformin and ginseng extract on improvement of polycystic ovary syndrome based on changes in LH, FSH, estrogen, and progesterone hormones. 63 adult female rats were used in this research and divided into 9 groups of 7 each as healthy control (without receiving any substance), patient control (estradiol valerate), patient sham (estradiol valerate + distilled water), healthy sham (distilled water), experimental1 (estradiol valerate + metformin), experimental2 (estradiol valerate + ginseng), experimental3 (estradiol valerate + metformin + ginseng), experimental4 (estradiol valerate + ginseng), and experimental5 (estradiol valerate + metformin + ginseng). The results showed that simultaneously dose-dependent use of metformin and ginseng has better effect on improvement of hormonal changes in polycystic ovary syndrome.