Investigation of common genes for metabolic disorders: A bioinformatics approach
Tasnuba Jesmin, Sajjad Waheed, Abdullah-Al-Emran
The failure of metabolism process is resulted by metabolic disorder and growing interest worldwide. The purpose of this research is to investigate common genes that are shared by four metabolic diseases like OB, T2D, HT and CVD. Associated genes with specific metabolic disease have been accumulated from different world recognize databases. Initially 2794, 1520, 2531 and 4713 genes are collected respectively. Collected genes are verified and mined for the establishment of gene interaction models. It reduced 91.05%, 89.74%, 92.70% and 96.22% genes respectively. Sorting technique has been applied for arranging the collected genes separately. After completion of analysis 125, 108, 121 and 110 genes have been achieved respectively. 62 common candidate genes are determined. Finally, cross linkage process discovered 10 common genes and reduced 83.87% genes for four diseases. This research will be helpful not only to construct simple common metabolic pathway but also to target drug for metabolic diseases.