The current study aims at assessing the influence of pyrethroid resistance on the outcome of Plasmodium infection in Anopheles coluzzii populations. Mosquito larvae collected in the field were reared in the laboratory, and then separated into two groups. The first group was exposed to permethrin 0.75%, the second acted as control group. Experimental infections were conducted with the two groups with field isolates of Plasmodium falciparum by direct membrane feeding assay. Blood fed females were dissected 7 days later to detect oocyst infection. The prevalence of infection between resistant and control was 13.95% and 14.83%rnrespectively. The mean number of oocyst per infected gut in the resistant group was 4.95 whereas it was 3.98 for the control. No significant association between the knock down (kdr) allele presence and susceptibility to Plasmodium infection was detected. No influence of pyrethroid resistance on the outcome of infection was detected.