author(s)
Sanjay Singh, Abhay Singh Yadav

abstract
The present study was carried out to analyse the frequency of micronuclei (MN) and other nuclear anomalies in smoker COPD subjects. For the present study, a total of 110 COPD subjects were analysed out of which 77 were males (mean age 57.299±1.584 years), 33 females (mean age 55.424±1.630years), 49 smokers (mean age 57.347±1.954 years ), 61 non-smokers (mean age 56.246±1.528 years ) matched with respect to age, lifestyle and socioeconomic status with 90 controls out of which 63 males (mean age 52.444±1.974 years), 27 females (mean age 56.518±2.753 years), 31 smokers (mean age 50.968±2.717 years) and 59 non smokers (mean age 55.084±1.997 years). Nuclear anomalies were analysed using micronucleus assay. In smoker COPD subjects micronuclei (MN) frequency was significantly p<0.001 increased along with that the frequency of binucleate (BN), broken egg (BE), karyolysis (KL) and karyorrhexis (KH) were also increased. In case of KH the significant difference was observed at p<0.01.