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Journal of Entomology and Zoology Studies
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ISSN Print: 2349-6800 | ISSN Online: 2320-7078

Journal of Entomology and Zoology Studies

2016, Vol. 4, Issue 2
shRNAs: A few keypoints about their applications

S Abdolhamid Angaji, Sahar Mikaeeli, Sepideh Mikaeeli

Epigenetics modifications regulate and process gene expression through small and non-coding RNAs mechanism. In fact this mechanism which is termed “RNA interference (RNAi)” is a protected phenomenon in post-transcriptional or pre-transcriptional level which regulates the expression of different genes through microRNA (miRNA) and interfering RNA (siRNA). mRNA degradation is done by siRNA mechanism including siRNAs and shRNAs. These synthesized dsRNAs have a wide range of applications in targeting variety of genes and are sufficient tools for therapeutics aims. In this paper, we reviewed RNAi molecular mechanism and its application in common human cancers including cervical prostate, breast, lung, gastric, colon, head, neck, skin and oral cancers.
Pages : 252-256 | 1244 Views | 26 Downloads
How to cite this article:
S Abdolhamid Angaji, Sahar Mikaeeli, Sepideh Mikaeeli. shRNAs: A few keypoints about their applications. J Entomol Zool Stud 2016;4(2):252-256.
Journal of Entomology and Zoology Studies
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