S Abdolhamid Angaji, Sahar Mikaeeli, Sepideh Mikaeeli
Epigenetics modifications regulate and process gene expression through small and non-coding RNAs mechanism. In fact this mechanism which is termed “RNA interference (RNAi)” is a protected phenomenon in post-transcriptional or pre-transcriptional level which regulates the expression of different genes through microRNA (miRNA) and interfering RNA (siRNA). mRNA degradation is done by siRNA mechanism including siRNAs and shRNAs. These synthesized dsRNAs have a wide range of applications in targeting variety of genes and are sufficient tools for therapeutics aims. In this paper, we reviewed RNAi molecular mechanism and its application in common human cancers including cervical prostate, breast, lung, gastric, colon, head, neck, skin and oral cancers.