This study was conducted at Department of Zoology, University of Gujrat, Pakistan during April 2016- July 2016. The data for the last two decades regarding Mosquito behavior and plasmodium was compiled through a thorough review of research articles published in various journals of international repute. The main purpose of this review is to differentiate between plasmodium infected and uninfected female mosquito. Plasmodium manipulate the host to increase its own transmission. The most obvious changes induced in mosquito due to plasmodium is increase in its biting rate towards human host. Infected female bite more than uninfected female. Plasmodium increases the vector longevity for its own survival. The fecundity of plasmodium infected mosquito is greatly reduced. There is a modification in the head region of mosquito and protein expressions in infected and uninfected mosquito are different. So when we differentiate between infected and uninfected mosquitoes the control measures are very easy. Then we will focus on only infected mosquito and it will save the cost and time as well as environmental hazards are reduced.