Ticks are bloodsucking arthropods mandatory and represent a real problem for cattle. The aim of this review is to make an inventory of acaricide resistance and ways to fight against the tick Rhipicephalus microplus. The main classes of synthetic miticides are arsenical, organochlorine, organophosphates, amidines, macrocyclic lactones, growth regulators and phenylpyrazoles. Pyrethroids are the most widespread and used acaricide in the fight against ticks. Resistance to these classes acaricide was reported in all countries where the tick Rhipicephalus microplus is present. To deal with these ectoparasites, a variety of control methods are used. These include ecological, biological, and genetic approaches. Proper control of the ticks will allow farmers to save and limit the losses related to diseases transmitted by ticks. It is urgent to propose and develop new approach to fight against tick Rhipicephalus microplus.