Antigenotoxic effect of turmeric powder extract curcumin against chromium trioxide induced genotoxicity in fish Channa punctatus
Rajesh Prasad, Manoj Kumar and Sunil P Trivedi
Curcumin is a yellow colour main polyphenolic compound which is isolated from dry rhizome of the plant Curcuma longa (family Zingiberaceae). The present study was designed to evaluate the antigenotoxicity activity of curcumin against chromium induced micronuclei induction in fish Channa punctatus. After 15 days acclimatization, the fish were divided in six groups. In group III the induction of micronuclei increased significantly (p<0.05), when this group was exposed with only LC50/10 (7.89mg/l) of chromium in comparison to group I for 24hr, 48hr, 72hr and 96hr. In groups IV, V and VI the increased induction of micronuclei were found reduced after simultaneous exposure of curcumin along with chromium in comparison to group I and group II. The outcome of this study shows that curcumin is a good antigenotoxic agent against chromium in time and dose dependent manner for fish C. punctatus. The finding of our study is also useful for aquaculture because curcumin is an excellent genoprotective agent against chromium toxicity.