Heterogeneous geographic distribution of human T-cell lymphotropic virus I (HTLV-I) and epidemiological, genomical, pathophysiologic, therapeutic knowledge about HTLV
Ikram Ullah, Tooba Iftikhar, Muhammad Ayub Jadoon, Mujaddad Ur Rehman, Qazi Sami ul Haq, Malik Naveed Akhter, Muhammad Zahid Khan, Attia Rehman, Maria Bibi and Kanwal Urooj
Human T-Cell leukemia Virus-1 also called the adult T-cell lymphoma virus type 1, is a retrovirus of the human T-lymphotropic virus (HTLV) family, responsible for various life threatening diseases such as Adult T-cell Leukemia (ATL) chronic inflammatory CNS disease named as Tropical Spastic Parapariesis/ HTLV-1 Associated Myelopathy (TSP/HAM). About 1–5% of infected persons are thought to develop cancer as a result of the infection with HTLV-I over their lifetimes. It is also observed that majority of the carriers of HTLV-1 remains asymptomatic throughout their whole life. Genetically factors and immunological status of the host determines the causation of associated diseases of HTLV-1. The objective of this review is to provide a good update on epidemiological, genomical, pathophysiologic, therapeutic knowledge about HTLV, and also provide knowledge about diagnostic suspicion and criteria, treatment, transmission and prevention of the disease.
Ikram Ullah, Tooba Iftikhar, Muhammad Ayub Jadoon, Mujaddad Ur Rehman, Qazi Sami ul Haq, Malik Naveed Akhter, Muhammad Zahid Khan, Attia Rehman, Maria Bibi, Kanwal Urooj. Heterogeneous geographic distribution of human T-cell lymphotropic virus I (HTLV-I) and epidemiological, genomical, pathophysiologic, therapeutic knowledge about HTLV . J Entomol Zool Stud 2017;5(2):871-878.