author(s)
Ritesh Jaiswal, SL Ali, S Roy, S Sakya, OP Dinani and Sudhir Kumar Jaiswal

abstract
In the present study effect of lead intoxication on serum biochemical of broiler chicken has been done. The birds were divided into six groups viz. A, B, C, D, E and F. Group-A served as control whereas group-B received lead acetate @ 200 mg/kg basal diet for 42 days simultaneously Ascorbic acid @ 200 mg/kg basal diet, Vitamin-E @ 100/mg/kg and Se @ 0.1 mg/kg basal diet, DL-methionine @ 100 mg/ kg and methanolic extract of Cissus quadrangularis (CQE) @ 400 mg/kg basal diet were given to group B, C, D, E and F respectively. The biochemical profile of treated with various levels of antioxidants on day 21 and 42 were reported total protein (6.05±0.47 to 6.85±0.39 and3.83±0.09 to 4.60±0.29 ), albumin (2.77±0.09 to 3.77±0.24 and 2.25±0.09 to 2.95±0.16 ), albumin: globulin ratio (0.74±0.04 to 1.89±0.49 and1.08±0.13 to 2.06±0.25 ), Serum glutamic oxaloacetic transaminase (1.26±0.16 to 2.62±0.13 and 0.96±0.16 to1.72±0.19 ), Serum glutamic pyruate transaminase (14.07±1.08 to 17.28±0.90 and 8.88±0.25 to14.87±0.49 ), blood urea nitrogen (6.07±0.75 to 11.22±0.45 and 2.98±0.21 to 4.60±0.17), creatinine (0.64±0.05 to 1.50±0.09 and 1.56±0.19 to 2.20±0.15 ) and alkaline phosphatase (3.41±0.25 to 4.40±0.32 and 2.50±0.57 to 4.00±0.78 ). All biochemicals parameters in lead treated group were significantly different (P<0.05) from the normal range on day 21 and 42 as compared to various antioxidant treatments and control group. All the antioxidant treatments were found effective in bringing the biochemical parameters within the normal range. Methanolic extract of Cissus quadrangularis were reported to be most effective to ameliorate lead toxicity in broiler chicken.