author(s)
Mamillapalli Vani, SK Abdul Rahaman and Avula Prameela Rani

abstract
The present investigation has been carried out to evaluate the antiasthmatic activity by in vitro and in vivo models in guinea pigs followed by phytochemical characterization using Gas chromatography Mass spectrum analysis of the hydroalcoholic and acetone extracts of the stem extracts of Alternanthera sessilis. In histamine and acetylcholine-induced bronchospasm studies acetone extracts of the plant have significantly increased PCT 10.52 and 11.36 by Tukey’s test (**p<0.01), compared with control. Histamine and acetylcholine-induced ileum contraction studies also showed that the acetone extracts exhibited response was1.8 with 63.3% and 2.7 with 51% inhibition by Dunnett’s test (p<*0.05). The results of GC-MS analysis depicted following phytoconstituents with major peak area namely 79.29% methoxy-bis (cyclopentadiene), 2.83% 5,10-dihexyl-5,10-dihydroindolo[3,2-b]indole-2,7-dicarbaldehyde and 1.84% 1,2-bis[3,4-dimethoxy benzyl]-1,2-bis (methoxymethyl) ethane respectively. The results of present study suggest the usage of plant extracts as antiasthmatic agents due to the phytochemicals reported through GC-MS.