author(s)
Tahani SS Al-Azawi and Hayder S Rwayyih

abstract
The present experiment was designed to study the protective role of ALA on some related metabolic disorder parameters in intact and ovarictomized rabbits. A total of twenty rabbits (7-8 weeks) have been used in this study. Ovariectomy was performed to ten of them and the other ten rabbits were left with intact ovaries. The animals were divided equally in to four groups as follows: Group one (I+D): intact rabbits received distilled water. Group two (I+A): intact rabbits received alpha lipoic acid orally (10 mg/kg B.wt).Group three (O+D):Ovariectomized rabbits received distilled water. Group four (O+A): Ovariectomized rabbits received alpha lipoic acid orally (10 mg/kg B.wt). The daily administration of ALA for 30 days caused a significant (p≤0.05) decrease in platelets number(143.8 and 132.0×10³/mm compared with 175.6 and 248.8×10³/mm³ in intact and Ovariectomized groups respectively), cholesterol, triglyceride, TSH and serum glucose concentration in both treated. Moreover, the resulte of this experiment also showed that ALA supplementation has a protective role concerning the increase in coagulation and bleeding time. There is also a significant (p≤0.05) increase in HDL (84.80 and 86.74 mg/dl compared with 82.34 and 80.38 in intact and Ovariectomized respectively), GSH and insulin concentration in groups received ALA in both intact and Ovariectomized rabbits. The results confirm the protection action of ALA in intact and ovariectomized rabbits against the effect of some aged metabolic disorder parameters.