author(s)
Nabeel B Kadum and Oday K Luaibi

abstract
The objective of the experiment were determined the clinical, hormonal and histological changes in hypothyroidism local breed goats. The plans of experiment was carried out by using 15 goats aged between (1-2yeares) and 20-25kg of body weight (B.W.).The goats has separated of three collections randomly. The control groups (C) was showed healthy, while the induction groups (T1 and T2) were induced hypothyroidism by giving thiourea 50mg/kg body weight daily for one week without treated, however the induction group (T2) was treated iodine compounded,(potassium iodide 0.005mg/kg of body weight by oral daily and tincture iodine application skin weekly for 8week). The results of clinical examination of induction groups showed became dullness, lose appetite, lethargy, weakness, anemic, leg edema, constipation and alopecia, beside decrease significant in the respiratory, heart rate and body temperature, also the hormonal analysis Triiodothyronine (T3), thyroxine (T4) hormones levels showed significantly decrease while increased Thyroid stimulating hormone (TSH) level whereas the T2 group after treated with iodine compounds recovered in the second week and the hormonal analysis were showed return to normal range in 3-4 week after treatment. Whereas the histopathological changes were presented in T1 group hyperplasia and hypertrophy endothelial follicles, which projected in lumen, and congested blood vessels, but the T2 groups were showed decrease size of endothelial cell (flatted), with increase of the colloid and collagen fibroses with lymphocyte filtration in interstitial tissue. The conclusion of the study could be iodine compounds to the therapeutic iodine deficiency.