Effect of toxic dose of levamisole on electrocardiogram and serum enzymes concentration in lambs
Alaa KM AL-Salmany and Zainab Alaa
The present study was conducted to assess probable organ and system defect related with levamisole poisoning experimentally in lambs. For this reason, fifteen healthy lambs (five lambs of each group different breeds genders, were aged from 1-3 months. in Baghdad city / Iraq (between October 2016 to December 2017).The lambs poisoning by levamisole in the present study was showed a significant increase of serum aspartate aminotransferase (AST) 98.34±2.52 mmol/l after 96 hr and alanine aminotransferase (ALT) 32.11±0.13 mmol/l after 144 hr. alkaline phosphatase (ALP) 30.17±5.31 mmol/l) after 96hr. but no significant increase in the cardiac troponin I. was observed. Electrocardiographic changes many arrhythmias such as sinus tachycardia, ventricular premature contraction, increase in P amplitude, PR interval, and T-wave inversion were recorded in the experimental sheep.Levamisole poisoning seems to cause numerous arrhythmias in sheep which might be due to the effect of Levamisole poisoning on the myocardium pathological. We the present concluded that the lambs were drenched in a dosage of 25 mg/kg body weight causes signs of poisoning and changes in the biochemical, and electrocardiographic pattern.