Effect of Eruca sativa leaves extract on liver enzymes and lipid profile in phosphoric acid induced liver damage in male rabbits
Sawsan Kadhim Mashi
This study was conducted on the male rabbits to investigate the effect of Eruca sativa on the liver enzyme and lipid profile in damaged liver induced by phosphoric acid. Twenty healthy adult male rabbits were used during the period from 1 to 31 March 2017. Animals were randomly separated into four equal groups (5 rabbits / group) and treated for 30 days as the following: 1st group was a control group (C): rabbits were permitted to ad libitum provide of drinking water, 2nd group (T1): were allowed to drinking water containing 1/10 of lethal dose1530 mg /kg b.w of phosphoric acid, 3rd group (T2): were received 250 mg/ kg b.w aqueous extract of Eruca Sativa orally and 1/10 of lethal dose1530 mg /kg b.w of phosphoric acid, 4th group (T3): were received 250 mg/ kg b.w aqueous extract of Eruca Sativa orally. Fasting samples were collected after 30 days of the experimental to estimate liver enzymes and liver profile. The results revealed that oral intubation of phosphoric acid for 30 days caused hepatic dysfunction manifested by a significant elevation(P<0.05) in the serum AST(83.00 u/L), ALT(44.20 u/L), cholesterol(74.60 mg/dL), triglyceride(224.80mmol/L), LDL-C (77.90 mg/dL) and VLDL-C (44.96 mg/dL) in the T1.Also phosphoric acid caused a significant decreasing(P<0.05) in HDL-C(31.96 mg/dL), while the animals received Eruca Sativa with phosphoric acid (T2)for 30 days showed a considerable decreasing (P<0.05) in the levels of AST (30.60 u/L), ALT (24.60 u/L),triglyceride(124.80 mmol/L) and cholesterol (71.40 mg/dL). However the increasing in HDL-C (45.98 mg/dl) was not significant as compared with control but the increasing was significant (P<0.05) with the other groups. The histological section showed the pathological changes in the liver tissue in T1 group while giving Eruca Sativa extract with and without phosphoric acid was effective in modified these changes into semi normal.