Day old broiler chicks (n=60) were divided into four groups comprising 15 birds in each. Group I served as control, group II was treated with chlorpyrifos @ 50 ppm in feed, group III was treated with cow urine distillate @ 10 ml/litre of drinking water, group IV was treated with chlorpyrifos @ 50 ppm and cow urine distillate @ 10 ml/litre of drinking water for a period of 28 days. Few birds from group II exhibited closed eyes and diarrhoea. Significant decrease was noted in body weight gain of group II whereas improved body weight gain was noted in group IV. Differences of TEC, MCV and MCH were found to be significant between different treatment group birds. The significant decrease in TLC values was recorded in groups II however; progressive increase was recorded in group IV. The significant decrease in lymphocytecount and increase in heterophil count was observed in group II. Co-administration of cow urine distillate against chlorpyrifos restored these changes in group IV. This study indicated that, subacute exposure of chlorpyrifos @ 50 ppm in feed has adverse effect on clinical and haematological observations and co-administration of cow urine distillate ameliorated these changes.