This paper presents the zinc responsive dermatitis and its successful management in dogs. The study included 9 dogs of various breeds, presented to the hospital with the history of erythema lips, crust lesions, hypotrichosis on lips, chin, around the nose and in the interdigital area and 6 healthy animals as a control. The Hb, PCV, TEC, Albumin, glucose and plasma zinc were signiï¬cantly (p<0.05) decreased whereas TLC; globulin and copper were significantly (p<0.05) increased. All the animals were treated with zinc sulphate @10mg/kg orally, daily for 14 days and the animals revealed a marked improvement in clinical signs and hemato-biochemical parameters.