author(s)
Nida Handoo, Jalal-ud-Din Parrah, Mohmmad Abrar Gayas, Syed Bisma and Masood Saleem Mir

abstract
In the present investigation, the efficacy of Rheum emodi and its different extracts in the healing of full-thickness skin wounds of rabbits was evaluated with a focus on qualitative and quantitative histopathological changes. 30 clinically healthy rabbits of either sex, randomly divided into 5 equal groups, of 6 animals each. In group 1, povidone iodine ointment was used, which served as a control. The animals of group 2 were treated with crude dust powder of R. emodi, group 3 with 10% ethanolic extract ointment, group 3 with 10% aqueous extract ointment, group 4 with 10% petroleum ether extract ointment of R. emodi. General anesthesia was induced using xylazine and Ketamine Hydrochloride. Two full thickness cutaneous wounds (1.5 x 1.5cm) were created on either side of dorsal spine in the thoraco-lumbar region. Present work suggested that Rhuem emodi and its extracts accelerate the inflammatory reaction and initiate early phase of healing. Extract treated groups showed better and faster healing than dust treated and control group.