In the present study arsenic-induced histological alterations in rats studded. The Wistar rats were divided into 3 groups and treated as follows: Group 1: Control, 2: mild arsenic treated (sodium arsenite @ 5 mg/kg b. wt orally for 4 wks), 3: arsenic treated (sodium arsenite @ 10 mg/kg b. wt orally for 4 wks). Group 3 (arsenic treated) showed marked degenerative changes in heart, kidney, liver, testis, lung, intestine and stomach. Group 1 and Group 2 did not reveal any abnormalities on histopathology.