Pharmacokinetic of single dose intramuscular administration of cefquinome using microbiological assay in goats
M Champawat, LN Sankhala, P Sharma and A Gaur
The present study was planned to investigate the disposition kinetics of cefquinome at the dose rate of 2 mg kg-1body weight intramuscularly in healthy marwari male goats at the Livestock Research Station, Kodamdesar, Rajasthan University of Veterinary and Animal Sciences, Bikaner in the month of October, 2016. Plasma concentrations were determined by microbiological assay method using MTCC equivalent (MTCC 1541) of Micrococcus luteus (ATCC 9341) as the test organism. Following intramuscular administration of cefquinome, peak plasma concentration (Cmax) was achieved 5.10 ± 0.51 μg ml-1at 1 h (tmax). Absorption half-life (t1/2ka), elimination half-life (t1/2β), area under the plasma concentration time curve (AUC) and volume of distribution (Vdarea) were 0.29 ± 0.04 h, 1.48 ± 0.04 h, 14.44 ± 0.82 μg ml-1h and 0.29 ± 0.02 L kg-1 respectively. In the present study, the plasma levels above the MIC level were maintained up to 6 h following intramuscular administration of cefquinome so as per the general recommendation that T>MIC should be at least 50% of dosage interval for optimum bactericidal effect, a 12 h dosing interval at the rate of 2 mg kg-1 is recommended intramuscularly in goats.
M Champawat, LN Sankhala, P Sharma, A Gaur. Pharmacokinetic of single dose intramuscular administration of cefquinome using microbiological assay in goats. J Entomol Zool Stud 2018;6(3):1825-1828.