Neglected Parasitic infections (NPIs)are group of parasitic infections which are common in low income populations those who struggle to meet their daily basic needs and inaccessibility of primary health care services. The reason behind NPI’s are may be poor population with low visibility and little political voice and also may be due to the lack of awareness of clinician and poor availability of optimal diagnostic tests. Confirmatory diagnosis of these parasitic infections requires well established lab, reagents, advance diagnostic methods. Therefore, there is an urgent need to develop improved diagnostic methods. According to recent report of World Health Organization (WHO) there is salient achievements related to decrease in number of new cases of certain disease including Visceral Leishmaniasis (VL), Lymphatic filariosis (LF), Human African Trypanosomiasis (HAT), Oncocersiasis by implementation of proper control strategies including preventive chemotherapy, innovative and intensified disease management, vector ecology and management, veterinary public health services, and the provision of safe water, sanitation and hygiene.