author(s)
Robin, SK Jain, Vikas and Sunil Kumar

abstract
This experiment was conducted to evaluate the ameliorating effect of Withania somnifera and resveratrol against induced biochemical changes by combined exposure of cypermethrin and deltamethrin in rats during month of June, 2017.The combined exposure of cypermethrin and deltamethrin was given in adult male Wistar rats. Various biochemical parameters were analysed up to 28 days and their amelioration by Withania somnifera and resveratrol on various biochemical alterations was investigated. Cypermethrin and deltamethrin was given orally at rate of 75mg/kg and 4mg/kg body weight in adult male Wistar rats. Rats did not exhibit any marked changes in their gross behavioural signs and symptoms. The combined exposure of cypermethrin and deltamethrin caused significant increase in ALT (61.28 IU/L), AST(161.38 IU/L), GGT(6.82 IU/L), BUN(64.96mg/dl) and creatinine (4.09 mg/dl) levels in rats. In cypermethrin plus deltamethrin plus Withania somnifera group and cypermethrin plus deltamethrin plus resveratrol group, both Withania somnifera and resveratrol co-treatment restored the changes to near normal observed following combined cypermethrin and deltamethrin exposure in rats. The present study showed that combined cypermethrin and deltamethrin exposure cause biochemical alterations in rats which is reversed and restored to normal values following co-treatment with Withania somnifera and resveratrol. This indicates the ameliorating effect in rats exposed to cypermethrin and deltamethrin combination .