author(s)
Om Prakash, S Gomathinayagam, TJ Harikrishnan, M Raman, V Pandiyan and Samapika Sahoo

abstract
The Haemonchus contortus (H. contortus), parasitic gastrointestinal nematode is of important concern for sheep and goat industry. Commonly known as the barber’s pole worm, abomasual worm, wire worm H. contortus can affect a great damage to a flock or herd of sheep and goat within a short period of time. Presentexperiment was conducted to evaluate the rational compounds to potentiate the efficacy of ivermectine in resistant H. contortus sheep and goat.Larval migration inhibition assay (LMIA) were carried out to assess the potentiation effect of ivermectin resistant H. contortus. In LMIA, 42% of the samples were ivermectin resistant with LM₅₀ value of 0.149. Curcumin, Quercetin, Kaempferol, Phloretin, Verapamil and Loperamide were selected for this study and In vitro reversal of ivermectin resistance in H. contortus with co-incubation compounds were carried out. The potentenciation efficacy of ivermectin was noticed with highest concentration of chemo sensitizers with LM₅₀ of resistant larvae dropping from 0.14902, to 0.0005, 0.0031, 0.0015, 0.0089, 0.0041 and 0.0046 for Verapamil, Loperamide, Quercetin, Kaempferol, Phloretin and Curcumin respectively.