author(s)
Robin, Pooja Kundu, Nikita, Vikas, Sunil Kumar, NS Meena, Pinki Rani and Vivek

abstract
This experiment was conducted to evaluate the ameliorating effect of Withania somnifera and resveratrol against induced changes in body weight gain, relative body weight gain and relative organ weight by combined exposure of cypermethrin and deltamethrin in rats during month of June, 2017.The Cypermethrin and deltamethrin are synthetic pyrethroid insecticides used for pest control in agriculture and as acaricide in animals. The MTD of cypermethrin and deltamethrin in adult male Wistar rats was determined to be 750 mg/kg and 40 mg/kg orally in a pilot dose range finding study. Body weight of each rat was recorded on alternate day till completion of experiment and changes in weight of various body organs (liver, kidney and brain) were examined after sacrifice. Combined treatment of cypermethrin and deltamethrin resulted in decreased body weight gain (both absolute and relative) as compared to naive. A significant change was also observed in relative organ weight in combined cypermethrin and deltamethrin treated groups as compared to naïve which was restored by Withania somnifera and resveratrol co-treatment. The study revealed a mild to moderate toxic effect of combined treatment of cypermethrin and deltamethrin on body weight gain and relative organ weight and these toxic effects was ameliorated by Withania somnifera and resveratrol.