author(s)
MA Hassan, T Rahaman, KA Ferdous, MNH Parvez and MS Islam

abstract
The irrational use of diazinon in our country can play a crucial role in the occurrence of many diseases of animals and human. The present study was conducted to investigate the alteration of gross & microscopic study of various organs, hematological parameters of rabbit as effect of insecticide (Diazinon). A total number of 16 male rabbits were assigned into four group. Control group received only basal diet and the other groups T₁, T₂ and T₃ received diazinon with supplemented feed at a dose level of 15, 30 and 45mg/kg feed respectively. Remarkable decreased in weight gain in T3 group. Diazinon caused elevation of SGPT/ALT (P<0.01), serum creatinine level attributed to pathological lesions. Histopathological lesions in liver included cirrhosis and necrosis in only (T₂ & T₃) treated groups. In kidney, glomerulus was filled with reactive cells in group T₁. There was slight loss of normal histological structure of pancreas in group T₁ rather than group T₂ & T₃.