author(s)
Vipul Chaudhary, Varun Anand and Pamela Singh

abstract
Diarrhoeal disease is one of the major public health concerns and represents the second most cause of mortality among children below 5 years of age in developing countries. Globally Rotavirus is transmitted by the fecal oral route, causes life intimidating gastroenteritis amongst human and cattle which has enforced the focused efforts to develop vaccines by understanding narrative therapeutic mechanisms of gastrointestinal virus pathogenesis. Rotavirus is the most common and contagious virus that cause diarrhea in infants and viral diarrhea in calves. Therefore worldwide endogenous government health policies and WHO have taken vast preventive and controlling measure to overcome the disease burden of Rotavirus.