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Journal of Entomology and Zoology Studies
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P-ISSN: 2349-6800, E-ISSN: 2320-7078

Journal of Entomology and Zoology Studies

2019, Vol. 7, Issue 3
Association study of an SNP in TLR1 gene with susceptibility to bovine tuberculosis in cows

Ashish Bhaladhare, Ramji Yadav, Mohd Baqir, Anuj Chauhan, Arvind Sonwane, Amit Kumar, Ran Vir Singh, Sushil Kumar, Pushpendra Kumar, Subodh Kumar and Bharat Bhushan

Toll like Receptor 1 (TLR1) gene codes for a host pathogen recognition receptor that plays a vital role in the pathogen recognition and initation of immune response and is a suitable candidate gene for identifying genetic predisposition to infectious diseases like Bovine Tuberculosis (bTB). In the present study, an attempt was made to investigate the genetic polymorphism at SNP locus rs55617193 in TLR1 gene and explore association of genetic variants at this locus with susceptibility to bTB infection in cattle. In a population of bTB affected and healthy cows established using single intradermal tuberculin test; SNP under investigation was found to be polymorphic. SNP locus 55617193 in TLR1 gene was however found to be non- significantly associated with susceptibility to bTB in the study population. These findings need added validation in independent, large case-control population of bTB along with association studies of other SNPs in TLR genes.
Pages : 248-252 | 931 Views | 183 Downloads


Journal of Entomology and Zoology Studies Journal of Entomology and Zoology Studies
How to cite this article:
Ashish Bhaladhare, Ramji Yadav, Mohd Baqir, Anuj Chauhan, Arvind Sonwane, Amit Kumar, Ran Vir Singh, Sushil Kumar, Pushpendra Kumar, Subodh Kumar, Bharat Bhushan. Association study of an SNP in TLR1 gene with susceptibility to bovine tuberculosis in cows. J Entomol Zool Stud 2019;7(3):248-252.

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