author(s)
Ashish Bhaladhare, Ramji Yadav, Mohd Baqir, Anuj Chauhan, Arvind Sonwane, Amit Kumar, Ran Vir Singh, Sushil Kumar, Pushpendra Kumar, Subodh Kumar and Bharat Bhushan

abstract
Toll like Receptor 1 (TLR1) gene codes for a host pathogen recognition receptor that plays a vital role in the pathogen recognition and initation of immune response and is a suitable candidate gene for identifying genetic predisposition to infectious diseases like Bovine Tuberculosis (bTB). In the present study, an attempt was made to investigate the genetic polymorphism at SNP locus rs55617193 in TLR1 gene and explore association of genetic variants at this locus with susceptibility to bTB infection in cattle. In a population of bTB affected and healthy cows established using single intradermal tuberculin test; SNP under investigation was found to be polymorphic. SNP locus 55617193 in TLR1 gene was however found to be non- significantly associated with susceptibility to bTB in the study population. These findings need added validation in independent, large case-control population of bTB along with association studies of other SNPs in TLR genes.