author(s)
Dr. Srinivas Reddy Bellur, Dr. M Narayana Swamy, Dr. GP Kalmath, Dr. ShrikanthKulkarni, Dr. ML Satyanarayana, Dr. S Yathiraj and Dr. A Krishnaswamy

abstract
The present study was conducted to evaluate the influence of thyroid status on electrolyte profile in dogs with chronic kidney disease. A total of 72 client-owned dogs aged between two to ten years, presented to the Veterinary College Hospital, Bangalore were included in this study. The clinically healthy dogs were assigned to Group I. Euthyroid dogs with chronic kidney disease were in Group II and hypothyroid dogs with chronic kidney disease were assigned to Group III. The selected dogs were in the age ranges of 2-4, >4-6, >6-8 and >8-10 years comprising of six dogs in each age range. The dogs of various breeds and of either sex were included. Serum samples obtained were utilised for assay of serum electrolytes such as Na⁺, K⁺, Cl^-, Ca²⁺ and P_i. Group II had significantly higher Pi, K⁺ and significantly lower Na⁺ compared to Group I (control) at all age ranges. Group III had significantly higher P_i, K⁺ and significantly lower Ca²⁺and Na⁺compared to Group I at all age ranges. The Group III had significantly lower Ca²⁺ and significantly higher P_icompared to Group II at all age ranges. When the age ranges were compared, significantly higher Pi was noted in Group III at >8-10 years compared to 2-4 years and significantly higher serum K⁺ was noted at >8-10 years when compared to 2-4 years age range in all the groups of study indicating age related changes in the functioning of kidneys and thyroid gland. In the present study, it is concluded that renal dysfunction had marked influence on serum electrolyte profile, while, hypothyroidism had additive effect on renal functional parameters mainly indicating the exaggeration of renal dysfunction.