Strongylosis, caused by large and small strongyles, is considered as one of the most important internal parasitic disease entity caused by nematodes of family Strongylidae affecting >90% of equine population. Large strongyles like Strongylus vulgaris, S. edentates and S. equinus are generally recognized as the most important and pathogenic internal parasites in horses. Large strongyles show major pathogenesis that encompasses verminous arteritis, damage of visceral organs, embolism or thrombosis leading to death and is mainly attributed to migrating larvae of parasites. However, small strongyles (also called Cyathostomin) exhibit mild symptoms of diarrhea and loss of appetite and weight, poor hair coat, lethargy, peripheral oedema and disordered intestinal motility. Despite of adopting and implementing the latest diagnostic technique and treatment and control measures, still internal parasites remain one of the most important problems affecting the health and well-being of equines. Seasonal use of anthelmintic drugs and pasture management are the main strategic control to arrest the Strongyle infection and overcome anthelmintic resistance.