The papaya mealybug, Paracoccus marginatus (Hemiptera: Pseudococcidae) is a serious insect pest causing severe damage to papaya plants. Effectiveness of two insect growth regulators viz. Tacoma 40 SC (Buprofezin) and Heron 5 EC (Lufenuron), two bacterial fermented insecticides viz. Libsen 45 SC (Spinosad) and Suspend 5 SG (Emamectin benzoate) and one mixed formulation viz. Lumectin 10 WDG (Lufenuron + Emamectin benzoate) were evaluated against papaya mealy bug. The experiment was conducted under laboratory condition to investigate the time-oriented mortality of papaya mealybug after exposure with selected treatments. Results clearly showed that about 100% and 90% mortality were found from Tacoma 40 SC and Heron 5 EC at 7 DAT with their highest concentrations @ 1.0 ml/L and 2.0 ml/L respectively. Among bacterial fermented insecticides, Libsen 45 SC was found better than Suspend 5 SG regarding mortality. About 90% and 75% mortality was found from Libsen 45 SC @ 0.75 ml/L and Suspend 5 SG @ 1.25 g/L at 7 DAT respectively. Moreover, Lumectin 10 WDG, a combination of Lumectin and Emamectin Benzoate performed excellent efficacy while 100% mortality was recorded @ 1.25 g/L. The present study showed that each of the insect growth regulator and microbial biopesticides had significant effect against papaya mealybug. The mortality of papaya mealy bugs was gradually increased when insects and papaya plants both were directly treated with selected IGRs and biopesticides with increasing concentration level and time. Finally, it can be concluded that Tacoma 40 SC, Heron 5 EC, Libsen 45 SC and Lumectin 10 WDG would be alternate and promising options of conventional insecticides to the farmers to control papaya mealybug effectively.