Ten cows with the symptoms of swelling in various body parts, depression, anorexia, respiratory distress and history of ingestion of Mimosa invisa was attended. Two cows were reported to die just after showing the symptoms. On clinical examination, the cows were found to be restless, normal rectal temperature, elevated respiratory and heart rate with edema in jowl and perineal region and reduced urine output. Haematology reveals low haemoglobin, lymphocytosis and serum biochemistry showed significantly (P<0.01) higher level of serum aspartate aminotransferase, alanine aminotransferase, Blood Urea Nitrogen and creatinine. The cows were treated with anti-inflammatory, diuretics, liver stimulant and sufficient rehydration. Out of 8 cows, 6 cows responded to treatment, while 2 cows died 12 hours post-treatment.