author(s)
B Roopali, S Roy and M Roy

abstract
Oxidative stress is defined as an imbalance between the antioxidant defense systems and the rate of production of reactive oxygen species (ROS). While ROS production depends largely on the mitochondria, Thyroid hormones affect the cellular antioxidant status. The dogs presented to the Teaching Veterinary Clinical Complex, College of Veterinary Science & AH, Durg, private clinics and government Veterinary hospitals of Durg-Bhillai, Raipur and Rajnandgaon districts of Chhattisgarh for a period of two years from March 2018 to February 2020 were included for the present study. Thyroid hormones (tT3, tT4 and fT4), oxidative marker (TBARS) and antioxidant parameters (SOD, catalase and reduced glutathione) were estimated in hypothyroid and healthy dogs. In the present study, there was a significant decrease in tT3, tT4 and fT4 levels in hypothyroidism dogs as compared to healthy ones. The TBARS values in hypothyroidism positive dogs were significantly increased as compared to healthy control group. Hypothyroid dogs showed significant decrease in SOD, catalase and reduced glutathione values as compared to the healthy control group dogs.