author(s)
Dr. Ch. Mallikarjuna Rao, Dr. BN Nagaraja, Dr. RV Suresh Kumar, Dr. MS Vasanth and Dr. Suguna Rao

abstract
Septic arthritis is one of the important neonatal diseases in calves. Different types of treatments have been proposed by various authors but with minimal satisfactory results. In present research, we compared the efficacy of intra-articular infusion of chitosan drug delivery impregnated with ceftiofur sodium in group I and honey in group II. Haematological parameters like Hb, PCV, TEC, TEC and DLC were estimated before and 7^th, 14^th, 21^st and 28^th day post application in calves with septic arthritis. On day of presentation Hb, PCV and TEC were lower than their respective values on day 28 and parameters gradually increased to reach normal base values on 28^th day in both the groups. Significant increase in levels of TLC and neutrophil counts was noticed on day 0 which gradually declined to normalcy after initiation of treatment. Results proved that effective elimination of infection and all haematological parameters return normal after initiation of treatment.