author(s)
D Rani Prameela, D Sreenivasulu, Ch. Srilatha and P Vijayachari

abstract
Leptospirosis is a global important re-emerging disease of both humans and animals. The disease is a common zoonosis, acquired by exposure to infected animals or contaminated soil and water. Though the leptospira are potentially lethal, often undiagnosed. In the present study, histopathological studies were conducted in guinea pigs inoculated with leptospiral isolates recovered from sheep and pigs. Histopathological studies of liver and kidneys revealed congestion, hemorrhages, vacculation and infiltration of mono nuclear cells. The changes observed were due to Leptospirosis in liver and kidneys of guinea pigs. Re-isolation of leptospira could be made from cortical part of kidney and liver of guinea pig.