Stem cells are biological unspecialized cells that can differentiate into any specialized cells of the body. Regenerative medicine refers to the science of medicine which discusses the algorithm of healing by itself. Stem cells have been used to treat bone marrow diseases for decades but the potential of the stem cells in regenerative medicine has not been understood properly to date. The science of stem cells in treating the most dreadful diseases of the era sounds fascinating but it might be possible with stem cells. Stem cells are the most significant breakthrough in treatment in Central Nervous System disease, diabetes, bone disease, heart disease, renal injury, blood pathology, sterility, liver cirrhosis, and various others which have a prognosis of inevitable death. The various questions on its efficacy, tumorigenicity, preservation, side effects are still in the womb of time which needs further detailed research and clinical trials. It has been concluded with the obstacles and promising hope to treat the most dreadful diseases of the planet.