author(s)
Iboyi MO, Onekutu A and Dabo AG

abstract
This study investigates the biochemical and haematological variations occurring in mice infected with doses of Schistosoma mansoni cercariae using a mouse model. The study was conducted in Jos North Local Government Area of Plateau Sate Nigeria from March through April 2018. Nine female albino mice weighing averagely 20-45g were subdivided into three (3) groups. Group 1 and 2 were injected intraperitoneally with high dose (2ml) and low dose (1ml) of solution containing S. mansoni cercariae while the third group remained uninfected thus served as control. On the 30th day of experimentation blood samples were obtained for evaluation of haematological and biochemical parameters. The study showed a significant (P<00.05) difference in the enzymes and albumin (Alanine Transaminase, Aspartate Transaminase, Albumin) levels of the infected groups as compared to the control group. Lipid levels and electrolytes were also significantly different (P<0.05). Also recorded was a significant increase in hematological parameters (White Blood Count, Red Blood Count, Mean corpuscular volume, Mean Corpuscular Haemoglobin, Mean Corpuscular Haemoglobin Concentration, Platelets, Lymphocytes, Neutrophils, Monocytes) at P<0.05.