Blood transfusion is a method wherein one animal (recipient) receives with great caution the blood products (whole blood or part of blood) from another animal (donor) of the same species. For blood transfusion, it is important to know the blood volume and blood groups of each animal. The review gives an updated overview to the reader regarding the history, blood volume, blood group of animals and the process of blood transfusion in animals. The occurrence of various blood grouping systems in animals is of much concern to modern transfusion medicine. Blood banks could help to ease the process of transfusion of blood. We look into the future for enhanced ways to approach animals that needs a blood transfusion.