This paper reports a clinical management of the secondary complications of the lumpy skin disease in a cow. A cross bred cow with the complaint of widespread nodular eruptions on different parts of the body was presented during a awareness camp conducted by the team of experts. The detailed physical examination of the animal was conducted which revealed that the animal was febrile with rectal temperature of 40.2°C and had combination of small to large sized circumscribed nodules on various body parts, especially in the neck area. Also animal was showing a certain degree of lameness with significant swelling of prescapular lymph nodes. Based on the course of disease and typical clinical findings, the case was suspected to be a lumpy skin disease. During the course of the treatment, the animal starting showing the signs of respiratory distress with labored breathing, nasal catarrh and coughing. The case was managed successfully by the application of combination therapy and the animal recovered fully.