Silkworm pupae, an erstwhile overlooked by-product of sericulture, harbours a staggering array of bioactive compounds, including proteins, lipids, vitamins and amino acids, rendering them a veritable goldmine of biomaterials with breathtaking applications. Beyond their remarkable nutritional profile, silkworm pupae have been ingeniously repurposed in animal feed, pharmacology and even textile dyeing, demonstrating their astounding versatility. The pupae's singular composition has been leveraged to develop revolutionary sustainable biomaterials and groundbreaking pharmaceuticals, poised to transform various industries. Furthermore, their use as a natural fertilizer underscores their pivotal role in promoting sustainable agriculture. This review illuminates the astonishing multifaceted applications of silkworm pupae, highlighting their potential to catapult the sericulture industry into a lucrative and sustainable behemoth.