Effect of sodium fluoride on liver functions of rats and amelioration by CoQ10
Imtithal Ali Mohammed and Baraa Najim Al-Okaily
The present study was aimed to explore the protective role of Co enzyme Q (Co Q10) an antioxidant on hepatic dysfunction induced by sodium fluoride (SF) in adult male Wister rats. Twenty adult male rats were randomly assigned into four equal groups(five animals in each groups) and treated for 42 days daily as follows: first group was drenched drinking tap water, serving as control (group C),second group (group G1) received sodium nitrate 100ppm in drinking tap water to induce of liver toxicity along the experiment, third group (group G2) received sodium nitrate 100ppm in drinking tap water and was ameliorated with CoQ10 (10 mg /Kg. B.W) orally, while fourth group (group G3) were administered orally with CoQ10 at dose of 10 mg /Kg. B.W only. Fasting blood samples were collected at 0, 21, and 42 days of the experiment from orbital sinus to assess serum concentrations of total serum protein (TSP), albumin, globulin and total bilirubin (TB), as well as, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) activities. At the end of the experiment sections from the liver were obtained for histopathological study. The results revealed that rats received sodium fluoride (G1) caused significant decrease in total serum protein and albumin concentrations, whereas significant increase in ALT, AST, ALP and total TB concentrations accompanied with histopathological changes in liver tissue sections as compared to control and other treated groups. On the other hand, the protective role of CoQ10 was clarified in groups G2 including correction of above mentioned liver function testes and histopathological changes. In conclusion, the results of this study confirmed the protective role of CoQ10 as antioxidant against hepatotoxicity induced by sodium fluoride in adult rats.